Our bio-inspired interface is built upon a water-soluble multifunctional peptide with the ability to recognize and bind with high affinity to the surface of  titanium/titanium alloy implants. This peptide is joined  by a linker to a second peptide that activates specific host cell responses for more favorable outcomes leading to improved short and long-term success of the implant.

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For dental implants, the water-soluble material can be repeatedly applied at professional appointments to maintain the health of the implant and prolong its useful life. 

Recognition and binding to the titanium surface is coupled with biochemical signals to predictably control the host tissue response. 

Small peptides locally activate the Wnt-signal pathway to direct the differentiation of human stem cell to bone cells surrounding the implant serving to anchor it into the bone.

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In addition, small peptides with potent, broad-spectrum antimicrobial activity can be bound to the titanium surface to alter the oral microbial biome, reducing pathogenic species that elicit adverse inflammatory host responses leading to implant disease and loss.